Vitamin B6 (Pyridoxine)

vitamin b6What is Vitamin B6

Vitamin B6, also called pyridoxine, is among 8 B vitamins. All B vitamins assist the body convert food (carbs) into fuel (glucose), which is made use of to produce energy. These B vitamins, commonly referred to as B complex vitamins, likewise assist the body metabolize fats and protein. B complex vitamins are required for healthy skin, hair, eyes, and liver. They also help the nervous system function appropriately.

All B vitamins are water-soluble, indicating that the body does not keep them.

Vitamin B6 assists the body make several neurotransmitters, chemicals that bring signals from one nerve cell to another. It is required for typical brain advancement and function, and helps the body make the hormones serotonin and norepinephrine, which affect state of mind, and melatonin, which helps manage the body clock.

In addition to vitamins B12 and B9 (folic acid), B6 assists control levels of homocysteine in the blood. Homocysteine is an amino acid that might be connected with heart problem. Your body needs B6 in order to absorb vitamin B12 and to make red cell and cells of the immune system.

It is unusual to have a considerable shortage of B6, although researches suggest many people may be mildly lacking, particularly children and the senior. Certain medications can likewise cause low levels of B6 in the body. Signs of major shortage consist of muscle weakness, anxiousness, irritation, anxiety, trouble concentrating, and short-term memory loss.


 

Cardiovascular disease

It isn’t clear how vitamin B6 may impact heart disease. People who do not get adequate B6 in their diet have a greater risk of heart disease. And B6 contributes in decreasing levels of homocysteine in the blood. High levels of homocysteine seem associated with cardiovascular disease, however researchers have no idea precisely what the relationship is. They also do not understand whether reducing levels of homocysteine will decrease threat of heart problem. Until more is understood, the best action is to obtain enough B6 through food, and to take supplements if your medical professional recommends them.

Nausea and Vomiting throughout pregnancy (morning sickness)

Numerous researches, including one huge double-blind, placebo-controlled research study, found that an everyday dosage of 30 mg of B6 might help reduce morning illness. However, other studies have discovered no benefit. If you are pregnant, make sure to ask your physician before taking any supplements, consisting of vitamin B6.

Age-Related Macular Degeneration

One big research study discovered that ladies who took 500 mg of vitamin B6 daily along with 1,000 mcg of cyanocobalamin (vitamin B12) and 2,500 mcg of folic acid lowered their threat of establishing AMD, an eye condition that can cause loss of vision.

Anxiety

Vitamin B 6 assists your body make serotonin, a chemical that affects state of mind. Low levels of serotonin are associated with anxiety, and some antidepressant medications work by raising levels of serotonin. Some researchers believe that vitamin B6 might help in reducing signs of anxiety, however there isn’t any real proof yet. More research is required.

Premenstrual Syndrome (PMS)

Although some studies reveal that vitamin B6 may help enhance PMS symptoms, most of these studies were inadequately designed. Studies that were well created found no gain from B6. Up until more research is done, talk with your physician about whether utilizing B6 corrects for you. Some people who believe B6 is effective for PMS state it might take up to 3 months to see an obvious modification.

Carpal Tunnel Syndrome

Some early research studies suggested that B6 might help reduce inflammation and signs of carpal tunnel syndrome. However, the majority of the well-designed researches have actually discovered that it is ineffective.

Rheumatoid Arthritis

Low levels of vitamin B6 have been related to rheumatoid arthritis. Some researches also suggest that individuals with RA might need more vitamin B6 than healthy individuals because chronic inflammation may lower B6 levels. Consuming a healthy, balanced diet and taking a multivitamin is a great idea for anyone who has a chronic illness, such as rheumatoid arthritis. Speak with your physician prior to taking B6 supplements.

Tardive Dyskinesia

A few little research studies have actually discovered that vitamin B6 may improve symptoms of tardive dyskinesia compared with placebo. Tardive dyskinesia is an adverse effects of some antipsychotic drugs that are taken for a long while, and includes spontaneous motion of muscles, such as in the tongue, lips, face and jaw, arms, legs, fingers or toes.


 

Vitamin B6 Foods

Great food sources of vitamin B6 include chicken, turkey, tuna, salmon, shrimp, beef liver, milk, cheese, lentils, beans, spinach, carrots, brown rice, bran, sunflower seeds, wheat germ, and whole-grain flour.

Readily available Forms

Vitamin B6 can be discovered in multivitamins, consisting of children’s chewable and liquid drops, B complex vitamins, or can be offered independently. It is offered in a variety of forms, consisting of tablets, softgels, and lozenges. Vitamin B6 is also sold under the names pyridoxal, pyridoxamine, pyridoxine hydrochloride, and pyridoxal-5-phosphate.


 

The best ways to Take It

Individuals who consume a balanced diet plan ought to meet the daily requirement for vitamin B6 without taking a supplement. Just like all medications and supplements, consult a health care service provider before providing vitamin B6 supplements to a child.

Day-to-day recommendations for nutritional vitamin B6 are listed below.

Pediatric

Babies 0 – 6 months: 0.1 mg (sufficient intake).
Babies 7 months – 1 year: 0.3 mg (sufficient consumption).
Youngsters 1 – 3 years: 0.5 mg (RDA).
Youngsters 4 – 8 years: 0.6 mg (RDA).
Children 9 – 13 years: 1 mg (RDA).
Kids 14 – 18 years: 1.3 mg (RDA).
Girls 14 – 18 years: 1.2 mg (RDA).

Grownup

19 – 50 years: 1.3 mg (RDA).
Guy 51 years and older: 1.7 mg (RDA).
Females 51 years and older: 1.5 mg (RDA).
Pregnant ladies: 1.9 mg (RDA).
Breastfeeding ladies: 2.0 mg (RDA).
Larger dosages have actually been utilized in some studies, but you need to not take dosages above 100 mg per day without a healthcare carrier’s supervision. Big dosages of B6 may trigger nerve damage.


 

Vitamin B6 Side Effects

Since of the potential for adverse effects and interactions with medications, you must take dietary supplements only under the guidance of a well-informed health care service provider.

Really high doses 200 mg or more daily– of vitamin B6 can cause neurological conditions, such as loss of sensation in the legs and imbalance. Stopping high doses typically leads to a total recovery within 6 months.

There have actually been unusual reports of allergic skin responses to high dosages of vitamin B6 supplements.

Opposite results can consist of sensitivity to sunshine, queasiness, stomach pain, and loss of hunger.

Possible Interactions

If you are being treated with any of the following medications, you should not utilize vitamin B6 supplements without very first talking with your health care service provider.

Drugs that decrease levels of B6 in the body– If you take any of these medications, make certain to obtain enough B6 in your diet:

Cycloserine (Seromycin), utilized to treat tuberculosis.
Hydralazine (Apresoline), made use of to deal with high blood pressure.
Isoniazid, used to deal with tuberculosis.
Penicillamine, used to deal with rheumatoid arthritis.
Theophylline (TheoDur), utilized to treat asthma.
Antibiotics, Tetracycline– All B complex vitamins, including vitamin B6, disrupt the absorption and efficiency of antibiotic tetracycline. You should take tetracycline at various times from vitamin B6 and other B vitamins.

Antidepressant Medications– Taking vitamin B6 supplements may enhance the effectiveness of some tricyclic antidepressants such as nortriptyline (Pamelor), particularly in elderly people. Other tricyclic antidepressants include amitriptyline (Elavil), desipramine (Norpramin), and imipramine (Tofranil).

On the other hand, antidepressants called monoamine oxidase inhibitors (MAOIs) may minimize blood levels of vitamin B6. Examples of MAOIs consist of phenelzine (Nardil) and tranylcypromine (Parnate).

Amiodarone (Cordarone)– This drug, used to treat an irregular heartbeat, makes your skin more conscious sunshine. Taking vitamin B6 together with this drug may increase your threat of sunburn, blistering, or a rash.

Chemotherapy drugs– Vitamin B6 may reduce certain negative effects of 5-fluorouracil and doxorubicin, medications used to treat cancer. Talk with your doctor before taking any supplement if you are undergoing radiation treatment.

Erythropoietin (EPO)– Erythropoietin therapy, utilized to treat serious anemia, might reduce vitamin B6 levels in red blood cells.

Levodopa (L-dopa)– Vitamin B6 lowers the effectiveness of levodopa, a medication used to treat Parkinson’s illness. However, it does not appear to have the same result on the mix of levodopa and carbidopa. Your physician may be able to identify a dose of B6 that can safely help reduce adverse effects of levodopa. Taking vitamin B6 together with levodopa ought to be done just under your physician’s supervision.

Phenytoin (Dilantin) Vitamin B6 makes phenytoin, a medication utilized to deal with seizures, less reliable.

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