Vitamin B3 (Niacin)

vitamin b3What is Vitamin B3 (Niacin)

Niacin and niacinamide are kinds of Vitamin B3. Vitamin B3 is found in lots of foods consisting of yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains. Niacin and niacinamide are likewise found in lots of vitamin B complex supplements with other B vitamins.

Niacin is utilized for high cholesterol. It is likewise used in addition to other treatments for flow issues, migraine headache, dizziness, and to minimize the looseness of the bowels connected with cholera. Niacin is also used for preventing favorable urine drug screens in people who take unlawful drugs.

Niacinamide is used for dealing with diabetes and 2 skin conditions called bullous pemphigoid and granuloma annulare.

Niacin or niacinamide is utilized for avoiding vitamin B3 shortage and related conditions such as pellagra. Each of these forms of vitamin B3 is utilized for schizophrenia, hallucinations due to drugs, Alzheimer’s disease and age-related loss of believing skills, chronic brain syndrome, depression, motion sickness, liquor dependence, and fluid collection (edema).

Some people make use of niacin or niacinamide for acne, leprosy, attention deficit-hyperactivity disorder (ADHD), amnesia, arthritis, preventing premenstrual headache, enhancing digestion, protecting versus contaminants and contaminants, lowering the results of aging, decreasing blood pressure, enhancing blood circulation, promoting relaxation, enhancing orgasm, and preventing cataracts.

Niacinamide is put on the skin for dealing with a skin condition called inflammatory acne vulgaris.


 

Health Benefits of Niacin
Natural Medicines Comprehensive Database rates effectiveness based on clinical evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The efficiency scores for NIACIN AND NIACINAMIDE (VITAMIN B3) are as follows:

High cholesterol. Just niacin seems to decrease cholesterol, not niacinamide. Some niacin products are FDA-approved prescription items for treating high cholesterol. These prescribed niacin products generally can be found in high strengths of 500 mg or greater. Nutritional supplement types of niacin normally been available in strengths of 250 mg or less. Considering that really high doses of niacin are required for high cholesterol, dietary supplement niacin usually isn’t suitable.
Treatment and prevention of niacin shortage, and specific conditions related to niacin deficiency such as pellagra. Both niacin and niacinamide are authorized by the U.S. Food and Drug Administration (FDA) for these uses. Niacinamide is sometimes preferred due to the fact that it doesn’t trigger “flushing,” (inflammation, itching and tingling), an adverse effects of niacin treatment.

Osteoarthritis. Taking niacinamide seems to enhance joint versatility and decrease pain and swelling. Some people who take niacinamide may be able to reduce conventional painkilling medications.
Alzheimer’s illness. Individuals who consume greater quantities of niacin from food and multivitamin sources seem to have a lower risk of getting Alzheimer’s disease than individuals who take in less niacin. However there is no proof that taking a stand-alone niacin supplement assists to prevent Alzheimer’s disease.
Solidifying of the arteries (atherosclerosis)
Minimizing the threat of a second heart attack in guys with heart or circulatory disorders
Looseness of the bowels from an infection called cholera
Diabetes, types 1 and 2
Prevention and treatment of cataracts, an eye condition

Attention deficit-hyperactivity condition (ADHD). There is conflicting proof relating to the effectiveness of niacinamide in combination with other vitamins for the treatment of ADHD.
Migraine headache
Lightheadedness
Anxiety
Motion sickness
Alcohol dependence
Improving orgasm
Acne
Other conditions
More evidence is needed to rate niacin and niacinamide for these uses.


 

How does it work?
Niacinamide can be made from niacin in the body. Niacin is transformed to niacinamide when it is taken in quantities greater than what is needed by the body. Niacin and niacinamide are easily liquefied in water and are well-absorbed when taken by mouth.

Niacin and niacinamide are required for the correct function of fats and sugars in the body and to preserve healthy cells. At high doses, niacin and niacinamide can have different effects. Niacin might assist people with heart disease since of its beneficial effects on clotting. It may also improve levels of a particular kind of fat called triglycerides in the blood. Niacinamide has no helpful impacts on fats and must not be made use of for treating high cholesterol or high fat levels in the blood.

Niacin deficiency can trigger a condition called pellagra, which triggers skin irritation, diarrhea, and dementia. Pellagra was common in the early twentieth century, but is less typical now, considering that foods are now fortified with niacin. Pellagra has been essentially gotten rid of in western culture.

People with poor diet, alcohol addiction, and some kinds of slow-growing growths called carcinoid growths may be at risk for niacin shortage.


 

Side Effects of Niacin
Niacin and niacinamide are LIKELY SAFE for many people when taken by mouth. A typical minor adverse effects of niacin is a flushing response. This might cause burning, prickling, itching, and soreness of the face, arms, and chest, in addition to headaches. Starting with small doses of niacin and taking 325 mg of aspirin prior to each dosage of niacin will help in reducing the flushing response. Generally, this reaction disappears as the body gets utilized to the medication. Liquor can make the flushing response worse. Avoid huge amounts of liquor while taking niacin.

Other small negative effects of niacin and niacinamide are stomach upset, intestinal gas, dizziness, discomfort in the mouth, and other problems.

When dosages of over 3 grams per day of niacin are taken, more severe adverse effects can take place. These consist of liver issues, gout pain, ulcers of the digestive tract, loss of vision, high blood glucose, irregular heartbeat, and other serious problems. Similar side effects can occur with huge dosages of niacinamide.

Some concern has actually been raised about stroke danger in individuals taking niacin. In one huge study, individuals who took high doses of niacin had a two-fold higher threat of stroke compared to those not taking niacin. However it is unclear if this outcome was due to niacin or some other unidentified factor. Previous research has not identified any stroke danger associated to taking niacin. Many specialists think that it is prematurely to jump to any conclusions about niacin and strokes.

Niacinamide is POSSIBLY SAFE when made use of properly in children.
Unique safety measures & warnings:
Pregnancy and breast-feeding: Niacin and niacinamide are LIKELY SAFE for pregnant and breast-feeding ladies when taken in the recommended amounts. The recommended amount of niacin for pregnant or breast-feeding ladies is 30 mg each day for women under 18 years of age, and 35 mg for ladies over 18.

Allergies: Niacin and niacinamide can make allergies more serious due to the fact that they trigger histamine, the chemical responsible for allergic symptoms, to be released.

Heart disease/unstable angina: Large amounts of niacin and niacinamide can increase the threat of irregular heartbeat. Use with care.

Diabetes: Niacin and niacinamide might enhance blood glucose. Individuals with diabetes who take niacin or niacinamide should inspect their blood glucose carefully.

Gallbladder disease: Niacin and niacinamide might make gallbladder condition even worse.

Gout: Large quantities of niacin or niacinamide may prompt gout pain.

Low blood pressure: Don’t take niacin or niacinamide if you have low blood pressure. Your blood pressure might drop too much.

Liver condition: Niacin or niacinamide may increase liver damage. Do not utilize them if you have liver disease.

Kidney condition: Niacin may build up in people with kidney condition and trigger damage. Do not use them if you have kidney illness.

Stomach or digestive ulcers: Niacin or niacinamide may make ulcers even worse. Don’t use them if you have ulcers.

Surgical treatment: Niacin and niacinamide may disrupt blood glucose control during and after surgical treatment. Stop taking niacin or niacinamide at least 2 weeks prior to an arranged surgical treatment.


 

Exist interactions with medications?
Moderate
Beware with this mix.
Liquor (Ethanol).
Niacin can cause flushing and irritation. Taking in alcohol along with niacin might make the flushing and itching even worse. There is likewise some concern that consuming liquor with niacin might enhance the possibility of having liver damage.
Allopurinol (Zyloprim).
Allopurinol (Zyloprim) is made use of to deal with gout. Taking large dosages of niacin may worsen gout and lower the efficiency of allopurinol (Zyloprim).
Carbamazepine (Tegretol).
Carbamazepine (Tegretol) is broken down by the body. There is some concern that niacinamide may reduce how quick the body breaks down carbamazepine (Tegretol). However there is not enough info to know if this is important.
Clonidine (Catapres).
Clonidine and niacin both lower blood pressure. Taking niacin with clonidine might trigger your blood pressure to become too low.
Medications for diabetes (Antidiabetes drugs).
Long-lasting use of niacin and niacinamide might increase blood glucose. By increasing blood sugar level, niacin and niacinamide may decrease the effectiveness of diabetes medications. Screen your blood sugar level closely. The dosage of your diabetes medication might need to be altered.

Some medications utilized for diabetes consist of glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), metformin (Glucophage), nateglinide (Starlix), repaglinide (Prandin), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications utilized for decreasing cholesterol (Bile acid sequestrants).
Some medications for reducing cholesterol called bile acid sequestrants can decrease just how much niacin or niacinamide the body absorbs. This might decrease the efficiency of niacin or niacinamide. Take niacin or niacinamide and the medications at least 4-6 hours apart.

A few of these medications used for decreasing cholesterol include cholestyramine (Questran) and colestipol (Colestid).
Medications utilized for decreasing cholesterol (Statins).
Niacin can negatively influence the muscles. Some medications utilized for reducing cholesterol called statins can likewise influence the muscles. Taking niacin in addition to these medications may increase the danger of muscle problems.

Some of these medications used for high cholesterol consist of rosuvastatin (Crestor), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), fluvastatin (Lescol), and simvastatin (Zocor).
Primidone (Mysoline).
Primidone (Mysoline) is broken down by the body. There is some concern that niacinamide may reduce how quick the body breaks down primidone (Mysoline). But there is insufficient information to know if this is important.
Probenecid.
Probenecid is made use of to deal with gout pain. Taking large dosages of niacin might aggravate gout and lower the effectiveness of probenecid.
Sulfinpyrazone (Anturane).
Sulfinpyrazone (Anturane) is made use of to treat gout. Taking huge doses of niacin may worsen gout pain and lower the effectiveness of sulfinpyrazone (Anturane).
Minor.
Be watchful with this mix.


Aspirin
Aspirin is typically made use of with niacin to reduce the flushing dued to niacin. Taking high doses of aspirin may lower how fast the body does away with niacin. This might cause there to be too much niacin in the body and potentially cause adverse effects. However the low doses of aspirin most frequently utilized for niacin-related flushing do not appear to be an issue.
Nicotine patch (Transdermal nicotine).
Niacin can often trigger flushing and wooziness. The nicotine patch can also trigger flushing and lightheadedness. Taking niacin or niacinamide and using a nicotine patch can increase the possibility of ending up being flushed and lightheaded.
Exist interactions with natural herbs and supplements?
Anti-oxidants.
A combination of niacin and the prescribed drug simvastatin (Zocor) raises HDL (high density lipoprotein) cholesterol (“great cholesterol”) in individuals with coronary heart problem and low HDL levels. But taking niacin together with combinations of anti-oxidants (selenium, vitamin C, vitamin E, and beta-carotene) seems to blunt this increase in HDL. It is not understood whether this result occurs in people who don’t have coronary cardiovascular disease.
Chromium.
Taking niacin and chromium together may decrease blood sugar. If you have diabetes and take chromium and niacin supplements together, monitor your blood glucose to make sure it does not get too low.
Herbs and supplements that might hurt the liver.
Niacin, specifically in higher doses can cause liver damage. Taking niacin along with other natural herbs or supplements that may hurt the liver could enhance this threat. A few of these items consist of androstenedione, borage leaf, chaparral, comfrey, dehydroepiandrosterone (DHEA), germander, kava, pennyroyal oil, red yeast, and others.
Kombucha tea.
There is some concern that kombucha tea may reduce niacin absorption. However this needs to be studied more.
Zinc
The body can make niacin. People who are malnourished and have niacin deficiency, such as chronic alcoholics, make additional niacin if they take zinc. There might be an enhanced threat of niacin-related adverse effects such as flushing and itching if niacin and zinc are taken together.
Are there interactions with foods?
Hot drinks.
Niacin can trigger flushing and itchiness. These impacts might be enhanced if niacin is taken with a hot drink.


Niacin Dosage
The following dosages have been studied in clinical research:.

BY MOUTH:.
For high cholesterol: The effects of niacin are dose-dependent. The most significant increases in HDL and decreases in triglycerides occur at 1200-1500 mg/day. Niacin’s biggest results on LDL take place at 2000-3000 mg/day.
To prevent heart problem in people with high cholesterol: Niacin 4 grams daily.
For avoiding and treating vitamin B3 deficiency: Doses of nicotinic acid and niacinamide are thought about equivalent. For moderate vitamin B3 shortage, niacin or niacinamide 50-100 mg each day is used. For pellagra in adults, niacin or niacinamide 300-500 mg daily is given in divided doses. For pellagra in children, niacin or niacinamide 100-300 mg daily is given up divided dosages. For Hartnup disease, niacin or niacinamide 50-200 mg daily.
For decreasing fluid loss caused by cholera contaminant: Niacin 2 grams daily.
To avoid type 1 diabetes in high-risk kids: Sustained-release niacinamide 1.2 grams/m ² (body surface area) daily.
To slow illness progression of recently detected type 1 diabetes: Niacinamide 25 mg/kg daily.
For treating osteoarthritis: Niacinamide 3 grams daily in divided dosages.
For reduced danger of cataracts: A daily dietary consumption of roughly 44 mg of niacin.
For avoiding Alzheimer’s condition: 17-45 mg of niacin from food and multivitamins. Food sources high in niacin consist of meat, fish, beans, nuts, coffee, and strengthened grains and cereals. Note that there is no dependable evidence that taking a stand-alone niacin supplement will assist to prevent Alzheimer’s illness.
The everyday suggested dietary allowances (RDAs) of niacin are: Infants 0-6 months, 2 mg; Infants 7-12 months, 4 mg; Children 1-3 years, 6 mg; Children 4-8 years, 8 mg; Children 9-13 years, 12 mg; Men 14 years and older, 16 mg; Women 14 years and older, 14 mg; Pregnant women, 18 mg; and Lactating females, 17 mg. The maximum day-to-day dose of niacin is: Children 1-3 years, 10 mg; Children 4-8 years, 15 mg; Children 9-13 years, 20 mg; Adults, consisting of Pregnant and Lactating ladies, 14-18 years, 30 mg; and Adults, including pregnant and breast-feeding women, older than 18 years, 35 mg.


 

Other names
3-Pyridine Carboxamide, 3-Pyridinecarboxylic Acid, Acide Nicotinique, Acide Pyridine-Carboxylique-3, Amide de l’Acide Nicotinique, Anti-Blacktongue Factor, Antipellagra Factor, B Complex Vitamin, Complexe de Vitamines B, Facteur Anti-Pellagre, Niacin-Niacinamide, Niacin/Niacinamide, Niacina y Niacinamida, Niacinamide, Niacine, Niacine et Niacinamide, Nicamid, Nicosedine, Nicotinamide, Nicotinic Acid, Nicotinic Acid Amide, Nicotylamidum, Pellagra Preventing Factor, Vitamin B3, Vitamin PP, Vitamina B3, Vitamine B3, Vitamine PP.

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